Novel role for E4 region genes in protection of adenovirus vectors from lysis by cytotoxic T lymphocytes

Authors
Kaplan, JM Armentano, D Scaria, A Woodworth, LA Pennington, SE Wadsworth, SC Smith, AE Gregory, RJ
Citation
Jm. Kaplan et al., Novel role for E4 region genes in protection of adenovirus vectors from lysis by cytotoxic T lymphocytes, J VIROLOGY, 73(5), 1999, pp. 4489-4492
Citations number
23
Categorie Soggetti
Microbiology
Journal title
JOURNAL OF VIROLOGY
ISSN journal
0022538X → ACNP
Volume
73
Issue
5
Year of publication
1999
Pages
4489 - 4492
Database
ISI
SICI code
0022-538X(199905)73:5<4489:NRFERG>2.0.ZU;2-9
Abstract
Target cells infected with adenovirus (Ad) vectors containing intact E3 and E4 regions were found to be relatively resistant to lysis by Ad-specific c ytotoxic T lymphocytes. Elements from both the E3 and the E4 regions were r equired for this effect, leading to the identification of a previously unde scribed role for E4 gene products in resistance to cytolysis.