Authors
Citation
Gd. Evans et Dj. Grimwade, Extramedullary disease in acute promyelocytic leukemia, LEUK LYMPH, 33(3-4), 1999, pp. 219-229
Citations number
86
Categorie Soggetti
Hematology,"Onconogenesis & Cancer Research
Journal title
LEUKEMIA & LYMPHOMA
ISSN journal
10428194
→ ACNP
Volume
33
Issue
3-4
Year of publication
1999
Pages
219 - 229
Database
ISI
SICI code
1042-8194(199904)33:3-4<219:EDIAPL>2.0.ZU;2-#
Abstract
All-transretinoic acid (ATRA) is currently recommended as standard treatmen
t for acute promyelocytic leukemia (APL). However there has been increasing
concern that ATRA is associated with unusual sites of relapse. Although th
ere is insufficient evidence so far to substantiate this, we review the pot
ential mechanisms by which ATRA may increase the incidence of extramedullar
y and, in particular, central nervous system (CNS) relapse.