Aa. De Maximy et al., Cloning and expression pattern of a mouse homologue of Drosophila sprouty in the mouse embryo, MECH DEVEL, 81(1-2), 1999, pp. 213-216
Signaling molecules belonging to the Fibroblast growth factor (Fgf) family
are necessary for directing bud outgrowth during tracheal development in Dr
osophila and lung development in mouse. A potential inhibitor of the Fgf si
gnaling pathway, called Sprouty, has been identified in Drosophila, We have
identified three potential mouse homologues of sprouty. One of them, calle
d Sprouty4, exhibits a very restricted expression pattern. At 8.0 dpc (days
post coitum) Sprouty4 is strongly expressed in the primitive streak region
. At 9.5 and 10.5 dpc, Sprouty4 is expressed in the nasal placode, the maxi
llary and mandibular processes, the otic vesicule, the second branchial arc
h, in the progress region of the limb buds and the presomitic mesoderm. Spr
outy4 expression is also detected in the lateral region of the somites. In
the developing lung, Sprouty4 is expressed broadly in the distal mesenchyme
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