De-noising algorithms based on wavelet thresholding replace smalt wavelet c
oefficients by zero and keep or shrink the coefficients with absolute value
above the threshold. The optimal threshold minimizes the error of the resu
lt as compared to the unknown, exact data. To estimate this optimal thresho
ld, we use Generalized Cross Validation. This procedure has linear complexi
ty and is fully automatic, i.e., it does not require an estimate for the no
ise energy. This gaper uses the method for wavelet transforms that map inte
ger gray-scale pixel values to integer wavelet coefficients. An image with
artificial noise is used to illustrate the optimality properties of the est
imator. Not all theoretical requirements for a successful application of th
e method are strictly fulfilled in the integer transform case. However, thi
s has little influence on practical results. (C) 1999 American Association
of Physicists in Medicine. [S0094-2405(99)00404-6].