Bj. Willett et Mj. Hosie, The role of the chemokine receptor CXCR4 in infection with feline immunodeficiency virus, MOL MEMBR B, 16(1), 1999, pp. 67-72
Infection with feline immunodeficiency virus (FIV) leads to the development
of a disease state similar to AIDS in man. Recent studies have identified
the chemokine receptor CXCR4 as the major receptor for cell culture-adapted
strains of FIV, suggesting that FIV and human immunodeficiency virus (HIV)
share a common mechanism of infection involving an interaction between the
virus and a member of the seven transmembrane domain superfamily of molecu
les. This article reviews the evidence for the involvement of chemokine rec
eptors in FIV infection and contrasts these findings with similar studies o
n the primate lentiviruses HIV and SIV (simian immunodeficiency virus).