Asymmetries in the distribution of light and neutral hydrogen are often obs
erved in spiral galaxies, Here, attention is drawn to the presence of large
-scale asymmetries in their kinematics. Two examples of kinematically lopsi
ded galaxies are presented and discussed. The shape of the rotation curve -
rising more steeply on one side of the galaxy than on the other - is the s
ignature of the kinematic lopsidedness. It is shown that kinematic lopsided
ness may be related to lopsidedness in the potential, and that even a mild
perturbation in the latter can produce significant kinematic effects. Proba
bly at least half of all spiral galaxies are lopsided.