PITYRIASIS-VERSICOLOR - CLINICAL-EXPERIENCE WITH LAMISIL(R) CREAM ANDLAMISIL(R) DERMGEL

Pityriasis versicolor is a chronic superficial fungal disease usually located on the upper trunk, neck or upper arms. Terbinafine is an oral ly and topically active allylamine antifungal derivative with a broad antifungal spectrum. Several studies have documented the high activity of terbinafine (Lamisil(R)) cream in the treatment of pityriasis vers icolor, with cure rates of 79-100% after 2-4 weeks of treatment. Lamis il emulsion gel (Lamisil(R) DermGel) is a new topical formulation that remains in the skin in high concentrations for several months after j ust 1 week of application. Recently, in a prospective, double-blind, p lacebo-controlled, randomised, parallel-group, comparative, multicentr e study, we have treated patients with pityriasis versicolor with eith er terbinafine 1% emulsion gel (Lamisil DermGel) or placebo gel. Sixty -one patients were included, 31 in the Lamisil DermGel group and 30 in the placebo gel group. The gel was applied once daily for 7 days and the patients were followed up for 8 weeks. Twenty-eight patients in th e active and 29 patients in the placebo group were evaluable for effic acy. Using the intent-to-treat efficacy analysis, 21/28 (75%) were cur ed in the Lamisil-DermGel-treated group compared to 4/29 (14%) in the placebo group. No side-effects were seen. In conclusion, Lamisil DermG el was well tolerated and superior to placebo in the treatment of pity riasis versicolor when applied once daily for 7 days.