A recently conjectured relationship between UV and IR cutoffs in an effecti
ve field theory without quantum gravity is generalized in the presence of l
arge extra dimensions. Estimates for the corrections to the usual calculati
on of observables within quantum field theory are used to put very stringen
t limits, in some cases, on the characteristic scale of the additional comp
actified dimensions. Implications for the cosmological constant problem are
also discussed. (C) 1999 Elsevier Science B.V. All rights reserved.