There is substantial evidence that intolerance arises from perceptions of d
ifference. A prevailing view holds that even if intolerance is understandab
le as a defense mechanism, or as an attitude intended to ward off threateni
ng groups and noxious activities, it often is the result of human irrationa
lity and indulgence of prejudice. This conclusion is supported by studies t
hat seem to demonstrate the apparent irrelevance of the actual level of thr
eat to levels of intolerance. These studies show human actions attendant to
diversity are caused by established convictions (i,e,, prejudice) rather t
han by the degree of threat. However, informed by theoretical approaches pr
ovided by neuroscientists, we report findings that threat is, indeed, a pro
vocative factor that modifies political tolerance in predictable ways. Prev
ious studies defined threat as probabilistic assessments of the likelihood
of bad events. When threat is defined as novelty and normative violations (
i.e., as departures from expected, or normal, occurrence), then consistent
relationships to intolerance are obtained.