Jp. Brandel et al., Creutzfeldt Jakob disease: diagnostic value of protein 14-3-3 and neuronalspecific enolase assay in cerebrospinal fluid., REV NEUROL, 155(2), 1999, pp. 148-151
We studied the diagnostic value of:detecting protein 14-3-3 and of assaying
neuronal specific enolase (NSE) in the cerebrospinal fluid of 150 patients
with suspected sporadic Creutzfeldt-Jakob disease registered in an epidemi
ology research program between 1991 and 1996. Sensitivity and specificity o
f these two tests were high. This study confirms results reported earlier a
nd authorizes a new definition of Creutzfeldt-Jakob disease which gives pro
tein 14-3-3 the same diagnostic value as EEG recordings for classifying spo
radic cases.