UNUSUAL CLINICAL-FEATURES AND EARLY BRAIN MRI LESIONS IN A FAMILY WITH CEREBRAL AUTOSOMAL-DOMINANT ARTERIOPATHY

Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a recently described inherited disor der. The pathologic gene maps on chromosome 19. The clinical spectrum of the disease consists of recurrent strokes, migraine, transient isch emic attacks, mood changes, and dementia. We report a genetically asse ssed CADASIL family with atypical clinical presentations of epileptic seizures, In two asymptomatic family members there were early brain ab normalities on MRI. Our report expands the clinical spectrum of CADASI L and suggests that it is possibly an undiagnosed disorder.