Squamous cell carcinoma of the glottic larynx: A review emphasizing the University of Florida philosophy

Background. Squamous cell carcinoma of the glottic larynx is strongly relat ed to cigarette smoking and excessive ethanol intake. It is the most common head and neck cancer other than skin cancer. Methods. We reviewed pertinent literature relative to etiology, epidemiolog y, and treatment results, with emphasis on the treatment philosophy at the University of Florida. Results. The goals of treatment are cure and retention of a functional lary nx. The probability of achieving both goals is high for patients with early disease. In contrast, a significant proportion of patients with advanced d isease may be cured but must have a total laryngectomy as part of the treat ment. Conclusions. Treatment options are influenced by the extent of disease and patient preference. Options include transoral laser resection, open partial laryngectomy, radiation therapy, and total laryngectomy. Adjuvant chemothe rapy may have a role in advanced disease.