Toxic ingestion of gamma-hydroxybutyric acid

Gamma-hydroxybutyric acid (GHB) has become a popular new drug of abuse. Its effects include euphoria and disinhibition, Recently, several cases hale b een reported in the literature of Life-threatening or lethal ingestions, We report the case of a 17-year-old male who became unresponsive after taking GHB, Gamma-hydroxybutyric acid is used outside the United States to treat narcolepsy. In the past, it was touted as a muscle-bulking aid and was take n by body-builders, It has also been implicated as a drug involved in "date -rapes." Patients who ingest excessive GHB have a markedly altered level of consciousness, as did the patient in this illustrative case. Neostigmine a nd physostigmine show promise as potential reversal agents. Gamma-hydroxybu tyric acid overdose should be considered in any patient with altered mental status and a history of recreational drug abuse.