Synthesis of the northern hemisphere of epothilone A by a ten-membered ring closing metathesis reaction

Authors
Gerlach, K Quitschalle, M Kalesse, M
Citation
K. Gerlach et al., Synthesis of the northern hemisphere of epothilone A by a ten-membered ring closing metathesis reaction, TETRAHEDR L, 40(18), 1999, pp. 3553-3556
Citations number
45
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
40
Issue
18
Year of publication
1999
Pages
3553 - 3556
Database
ISI
SICI code
0040-4039(19990430)40:18<3553:SOTNHO>2.0.ZU;2-1
Abstract
The synthesis of the strained epothilone analog containing a ten-membered r ing as well as the northern hemisphere of epothilone A is described. This a pproach, using the ring closing metathesis reaction, is a solution to the l ack of stereocontrol observed in the ring closing metathesis reaction utili zed in the synthesis of the epothilone backbone by other groups. (C) 1999 E lsevier Science Ltd. All rights reserved.