A novel method for peptide block synthesis using unprotected peptides

Authors
Ishihama, Y Ito, O Oda, Y Takenawa, T Iwakura, M
Citation
Y. Ishihama et al., A novel method for peptide block synthesis using unprotected peptides, TETRAHEDR L, 40(17), 1999, pp. 3415-3418
Citations number
10
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
40
Issue
17
Year of publication
1999
Pages
3415 - 3418
Database
ISI
SICI code
0040-4039(19990423)40:17<3415:ANMFPB>2.0.ZU;2-G
Abstract
An S-cyanocysteine-mediated alpha-carbon activation reaction was used for t he block synthesis of unprotected peptides. The repeated reaction using the S-cyanocysteinyl peptides as building blocks made it possible to ligate se veral peptide segments in order to synthesize larger peptides with natural amide bonding. (C) 1999 Elsevier Science Ltd. All rights reserved.