A synthetic approach to the plakortones

Authors
Bittner, C Burgo, A Murphy, PJ Sung, CH Thornhill, AJ
Citation
C. Bittner et al., A synthetic approach to the plakortones, TETRAHEDR L, 40(17), 1999, pp. 3455-3456
Citations number
5
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
40
Issue
17
Year of publication
1999
Pages
3455 - 3456
Database
ISI
SICI code
0040-4039(19990423)40:17<3455:ASATTP>2.0.ZU;2-O
Abstract
The reaction of Grignard reagents with alpha-hydroxy-gamma-ketclcarboxylic acids leads to the formation of tetrasubstituted gamma-butyrolactones, one of which was converted into a bicyclic lactone 10 via consecutive bromoacet ylation, Wittig cyclisation and hydrogenation. This represents an efficient methodology for the synthesis of the plakortones, 1-4. (C) 1999 Elsevier S cience Ltd, All rights reserved.