Acetophenone-based linker for solid phase synthesis of secondary amides and sulfonamides on the Multipin (TM) support.

Authors
Bui, CT Bray, AM Ercole, F Pham, Y Rasoul, FA Maeji, NJ
Citation
Ct. Bui et al., Acetophenone-based linker for solid phase synthesis of secondary amides and sulfonamides on the Multipin (TM) support., TETRAHEDR L, 40(17), 1999, pp. 3471-3474
Citations number
14
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
40
Issue
17
Year of publication
1999
Pages
3471 - 3474
Database
ISI
SICI code
0040-4039(19990423)40:17<3471:ALFSPS>2.0.ZU;2-#
Abstract
A new and simple linker has been developed for synthesis of secondary amide s and sulfonamides, This application is based on the reductive amination re action between the acetophenone subunit of the linker and a wide range of p rimary amines including aliphatic and aromatic amines. Cleavage is effected under mild acidic conditions (20% TFA/DCM) to release the products in good yield and purity. (C) 1999 Elsevier Science Ltd. All rights reserved.