Rw. Baker et al., Chirality transfer from a biphenyl axis to a spiro centre and its reverse:sequential self-immolation, TETRAHEDR L, 40(17), 1999, pp. 3475-3478
Schmidt reaction of (S)-1-(2,'4',6-trimethoxy-4,6'-dimethylbiphenyl-2-yl)et
hanone 8 furnished the expected amide 9 (43%) accompanied by (S)-2,7'-dimet
hoxy-3',5',6-trimethylspiro[cyclohexa-2,5-diene-1,1'-(1H)isoindole]-4-one 1
2 (30%) which on reduction with zinc and acetic acid and subsequent methyla
tion regenerated ketone 8. (C) 1999 Elsevier Science Ltd. All rights reserv
ed.