New 1,3-amino alcohols derived from ketopinic acid and their application in catalytic enantioselective reduction of prochiral ketones

Authors
Li, XS Yeung, CH Chan, ASC Yang, TK
Citation
Xs. Li et al., New 1,3-amino alcohols derived from ketopinic acid and their application in catalytic enantioselective reduction of prochiral ketones, TETRAHEDR-A, 10(4), 1999, pp. 759-763
Citations number
15
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON-ASYMMETRY
ISSN journal
09574166 → ACNP
Volume
10
Issue
4
Year of publication
1999
Pages
759 - 763
Database
ISI
SICI code
0957-4166(19990226)10:4<759:N1ADFK>2.0.ZU;2-U
Abstract
New 1,3-amino alcohols, (1S,2S)- and (1S,2R)-1-hydroxylmethyl-2-amino-7,7-d imethyl bicyclo[2,2,1]heptane (endo-4 and exo-4), were prepared from ketopi nic acid via oximation and reduction. The enantioselective borane reduction of prochiral ketones catalyzed by the borane complex of exo-4 was examined . (C) 1999 Published by Elsevier Science Ltd. All rights reserved.