The introduction of minimally invasive coronary artery bypass surgery has e
xpanded the technical armementarium for operative treatment of coronary art
ery disease. Minimal access surgery using partial sternotomy or anterior in
tercostal minimal thoracotomy can be combined with video-scopic techniques
or port-access-methods. Either atrio-aortal cannulation, femoro-femoral or
jugular-femoral connections to the pump are possible for extracorporal circ
ulation (ECC). Even endoluminar occlusion of the aorta and application of c
ardioplegia into the aortic root can be considered and applied, Extracorpor
al circulation has developed into a safe standardized method. As far as pat
hophysiology is concerned, the decision to use ECC or not is of much more i
mportance than the grade of invasiveness. Fundamentally we therefore need t
o distinguish between minimally invasive methods with and without ECC. Vide
o-assisted coronary surgery in hearts under hypothermia and fibrillation wi
th ECC is also recommended occasionally. Minimally invasive coronary artery
procedures on beating hearts without ECC have to be done in a stabilized a
nd bloodless operative field to allow the construction of high standard ana
stomoses between bypass grafts and coronary arteries. In practice, silicon
occluders, epicardial and myocardial suture occlusion and fixation, mechani
cal stabilization devices, and pharmacologic induction of bradycardia are u
sed. In principle a skilled surgeon should be familiar with all these metho
ds to select the most suitable solution for the special clinical problem. A
final judgement about each method is not possible up to now. High patient
numbers have to be recruited in the groups and subgroups due to low mortali
ty (1%) and morbidity (5%), otherwise statistical significance of the resul
ts cannot be gained.