The clinical experience with transmyocardial laser revascularization indica
tes that angina is relieved significantly, perfusion and treadmill toleranc
e are improved and hospital admissions are decreased. The exact mechanism f
or a laser revascularization linked improvement is still unknown. Transmyoc
ardial laser revascularization should be used only in highly selected cases
when conventional methods fail to improve patients symptoms. Further evalu
ation of the efficacy of the new indirect revascularization method in clini
cal (larger multicenter trials) and experimental studies to elucidate the m
echanism of TMLR is warranted. Experimental long-term studies to explain th
e mechanism are in progress.