The mechanism of death in patients struggling against restraints remains a
topic of debate. This article presents a series of five patients with restr
aint-associated cardiac arrest and profound metabolic acidosis. The lowest
recorded pH was 6.25; this patient and three others died despite aggressive
resuscitation. The survivor's pH was 6.46; this patient subsequently made
a good recovery. Struggling against restraints may produce a lactic acidosi
s. Stimulant drugs such as cocaine may promote further metabolic acidosis a
nd impair normal behavioral regulatory responses. Restrictive positioning o
f combative patients may impede appropriate respiratory compensation for th
is acidemia. Public safety personnel and emergency providers must be aware
of the life threat to combative patients and be careful with restraint tech
niques. Further investigation of sedative agents and buffering therapy for
this select patient group is suggested.