The objective of this study was to evaluate the clinical, radiological, and
echocardiographic findings in 11 neonates with aneurysm of ductus arterios
us presented in our institutions between 1993 and 1996, and to postulate a
new theory for the pathogenesis of this lesion. Medical records, radiograph
ic studies, and echocardiograms were reviewed. All infants underwent follow
-up echocardiograms every 2 to 3 days until the aneurysm spontaneously reso
lved or surgery was performed. The infants were predominantly term males; s
ix had evidence of fetal distress, two were diagnosed prenatally by fetal e
chocardiogram, chest X ray evidenced mediastinal mass in six patients. The
first echocardiogram showed structurally normal heart with an aneurysmal pa
tent ductus arteriosus. In eight patients the aneurysm completely resolved
by 5 to 10 days. One infant underwent surgical resection of the aneurysm af
ter observation for 11 days with no change in size. Thrombosis of the aneur
ysm was noted in two patients; both underwent surgery. Increasing reports o
f ductal aneurysms in infants may reflect the availability of high-resoluti
on echocardiography and more frequent use of echocardiography in the neonat
al intensive care unit. Spontaneous resolution occurred in the majority of
cases as in previous reports. We postulate that, at least in some cases, an
eurysm of the ductus arteriosus is a congenital lesion that may represent p
oststenotic dilation of the ductus due to turbulent flow through a stenotic
segment at its pulmonary artery end during fetal life. The presence of ane
urysm of the ductus arteriosus should be excluded in selected cases of feta
l distress, by fetal echocardiography.