Pleural mesotheliomas are rare primary tumors of the pleura. Three groups a
re classified under the term mesothelioma: 1) benign pleural mesothelioma f
or which complete surgical treatment is curative with a good prognosis; 2)
localized malignant mesothelioma which is 3 fibrosarcoma, best treated by w
ide en-bloc resection; 3) diffuse malignant mesothelioma which is mainly of
epithelial type. The prognosis is poor in spite of all therapeutic approac
hes using irradiation, chemotherapy and surgery, alone or in combination, a
nd long-term survivals are uncommon. Two surgical approaches are currently
available for patients with diffuse mesothelioma: radical extrapleural pneu
menectomy and pleurectomy/decortication. Rigourous combinations of multimod
ality therapy are needed to improve local control and survival.