Pd. Steinbach et al., FLUOROMETHOLONE-GENTAMICIN EYE DROPS VS FLUOROMETHOLONE-NEOMYCIN EYE DROPS FOLLOWING CATARACT-SURGERY, Clinical drug investigation, 13(5), 1997, pp. 242-246
This was a prospective randomised, investigator-masked, parallel-group
, single centre study that was performed to compare fluorometholune-ge
ntamicin eye drops with fluurometholone-neomycin eye drops in the cont
rol of ocular inflammation after cataract surgery. Ocular examinations
were carried out preoperatively and postoperatively on days 1 (baseli
ne), 3 and 6, 60 patients (30 in each treatment group) of both genders
undergoing cataract-lens implant surgery for visually disabling catar
act were enrolled in the study. The baseline parameters wen similar in
the two study groups. At day 6 after treatment (final postoperative v
isit), cells in the anterior chamber (p=0.004) and conjunctival hypera
emia (P=0.02) were statistically significantly less with fluorometholo
ne-gentamicin compared with fluorometholone-neomycin. Both treatments
were equally well tolerated. In conclusion, this study demonstrated th
at fluorometholone-gentamicin eye drops were more effective than fluor
ometholone-neomycin eye drops in the control of ocular inflammation af
ter cataract surgery.