The chronobiology of prostate-specific antigen (PSA): Case report and chrono-metaanalysis

The circadian profiles of circulating PSA of a 72-year-old man (FH) and of 11 other clinically relatively healthy men are compared. The time course of FH's PSA was also followed longitudinally with single samples for over 3 y ears. A transient peak in PSA exceeding the upper time-unspecified age-corr ected reference limit prompted a retrospectively premature biopsy which ind icated prostatitis. Watchful waiting and additional PSA determinations may be the preferred approach before biopsy, notably in the elderly, for reason s of cost and invasiveness of the procedure. The load associated with a bio psy is also evaluated by a cardiovascular response.