Manufacture of strontium-82/rubidium-82 generators and quality control of rubidium-82 chloride for myocardial perfusion imaging in patients using positron emission tomography

Authors
Alvarez-Diez, TM deKemp, R Beanlands, R Vincent, J
Citation
Tm. Alvarez-diez et al., Manufacture of strontium-82/rubidium-82 generators and quality control of rubidium-82 chloride for myocardial perfusion imaging in patients using positron emission tomography, APPL RAD IS, 50(6), 1999, pp. 1015-1023
Citations number
25
Categorie Soggetti
Multidisciplinary
Journal title
APPLIED RADIATION AND ISOTOPES
ISSN journal
09698043 → ACNP
Volume
50
Issue
6
Year of publication
1999
Pages
1015 - 1023
Database
ISI
SICI code
0969-8043(199906)50:6<1015:MOSGAQ>2.0.ZU;2-U
Abstract
We describe a protocol to manufacture Sr-82/Rb-82 generators and (RbCl)-Rb- 82 for myocardial imaging with PET. The generators are manufactured in 3 st ages: (1) preparation of a tin oxide column, (2) leak test of the generator column and (3) loading of the generator with Sr-82. The generators produce d sterile and non-pyrogenic (RbCl)-Rb-82 for i.v. injection. No significant Sr-82/Sr-85 breakthroughs were observed after elution with 20 l of saline. The automated system delivered human doses of (RbCl)-Rb-82 accurately. (C) 1999 Elsevier Science Ltd. All rights reserved.