Sa. Baker et Nj. Miller-ihli, Comparison of a cross-flow and microconcentric nebulizer for chemical speciation measurements using CZE-ICP-MS, APPL SPECTR, 53(4), 1999, pp. 471-478
A standard cross-how nebulizer and commercially available micro-concentric
nebulizer (MCN-100) have been compared for capillary zone electrophoresis (
CZE) inductively coupled plasma mass spectrometry (ICP-MS) measurements. Me
tallothionein samples were separated and detected to characterize the perfo
rmance of the two nebulizers for chemical speciation measurements. The MCN-
100 offered improved sensitivity and lower detection limits compared to the
cross-dow nebulizer, but provided slightly poorer resolution. The detectio
n limit for Cd-114 in metallothionein solutions was 90 ng/g with the cross-
flow nebulizer and 10 ng/g with the MCN-100 for similar to 4 nL injections.
These values correspond to absolute detection limits of 360 fg Cd in the i
njected sample with the cross-flow nebulizer and 40 fg Cd for the MCN-100.
Quantitation of Cd in metallothioneins (rabbit liver and horse kidney) with
the use of a well-characterized rabbit liver metallothionein sample as the
calibration standard is reported. Measured Cd concentrations agreed with r
esults obtained by both graphite furnace atomic absorption spectroscopy (AA
S) and solution nebulization ICP-MS.