We present the results of a study on the massive star population down to ab
out M-V similar to -3.1, or 12-15 M-., of the most luminous giant H II regi
ons in the nearby spiral galaxy NGC 2403, based on Hubble Space Telescope i
mages and ground-based spectrograms. Particular emphasis is placed on the d
istribution of the Wolf-Rayet and red supergiant stars and the information
they provide about the recent star-forming history of these large complexes
. We find direct evidence for the presence of Wolf-Rayet (WR) stars in five
of the six giant H II regions investigated; 25-40 WR stars are inferred fo
r the sole NGC 2403-I giant H II region. Red supergiant (RSG) stars are mai
nly distributed over a more extended halo, while the young blue stars and m
ost WR stars are in or close to a compact core. One appears to be seeing yo
ung cores of O and WR stars surrounded by older halos containing red superg
iants. We propose a scenario in which RSG stars belonging to an early phase
of star formation were followed by a more recent burst corresponding to a
very blue mean sequence. Delayed trigger with preheating over several 100 p
c by the first generation of massive stars allowed the build-up of the requ
ired confinement for the production of parsec-scale cluster cores with lumi
nosity up to a few times 10(6) L-.. Finally, we present some interesting ob
jects found in the field of NGC 2403 outside the giant H II regions, such a
s field WR stars, globular clusters and background galaxies.