Intravesical bacille Calmette-Guerin in the treatment of carcinoma in situor high-grade superficial bladder carcinoma after radiotherapy for bladdercarcinoma

Objective To evaluate the effectiveness and tolerance of endovesical bacill e Calmette-Guerin (BCG) after pelvic radiation therapy for bladder cancer i n patients with recurrence as carcinoma in situ (CIS) and/or high-grade sup erficial bladder cancer. Patients and methods In a prospective study, 13 patients were treated with weekly instillations of 81mg BCG Connaught for 6 weeks, for CIS and/or high -grade superficial bladder carcinoma. All had been treated previously with radical radiation therapy for bladder carcinoma. Results Five patients had no recurrences and six patients retained their bl adders, within a median follow-up of 74.5 months. Five patients progressed; two underwent radical surgery and are alive after 75 months of follow-up, and three died from the disease (two were high-risk surgical patients and o ne had metastatic disease). Another two patients died from intercurrent dis ease without bladder cancer. Eight patients were alive at a mean (SD, range ) follow-up of 85 (12, 65-97) months. Conclusion Intravesical BCG is useful for controlling CIS and/or high-grade superficial bladder carcinoma in irradiated bladders and has an acceptable local tolerance; more than a third of patients were free of disease and pr eserved their bladders. This proportion is acceptable in patients currently scheduled for cystectomy.