1998 Alfred Bader Award Lecture - Tangents and targets: The synthetic highway from natural products to medicine

Synthetic studies directed toward various classes of compounds including ta xoids and enediyne systems are described. These investigations include teth er-controlled imtramolecular Diels-Alder reactions, carbometallation routes to dienes and furans, the use of carbohydrate building blocks, pentadienyl indium reagents for tandem cycloadditions to steroid and triterpenoid skel etons, and the synthesis of taxamycins and revolveneynes and related cyclop hanes.