A novel screening method for combinatorial chemistry for low affinity interactions

Authors
Sugimoto, N Kazuta, H Zou, J Miyoshi, D
Citation
N. Sugimoto et al., A novel screening method for combinatorial chemistry for low affinity interactions, CHEM COMMUN, (8), 1999, pp. 677-678
Citations number
14
Categorie Soggetti
Chemistry
Journal title
CHEMICAL COMMUNICATIONS
ISSN journal
13597345 → ACNP
Issue
8
Year of publication
1999
Pages
677 - 678
Database
ISI
SICI code
1359-7345(19990421):8<677:ANSMFC>2.0.ZU;2-5
Abstract
A novel screening method for combinatorial chemistry was developed by utili zing the high binding affinity of the avidin-biotin complex(K-a = 10(15) M- 1), making possible the efficient detection of low affinity interactions be tween tryptophan and pentapeptides.