Biosynthesis of isoprenoids in Escherichia coli: stereochemistry of the reaction catalyzed by isopentenyl diphosphate : dimethylallyl diphosphate isomerase

Authors
Leyes, AE Baker, JA Hahn, FM Poulter, CD
Citation
Ae. Leyes et al., Biosynthesis of isoprenoids in Escherichia coli: stereochemistry of the reaction catalyzed by isopentenyl diphosphate : dimethylallyl diphosphate isomerase, CHEM COMMUN, (8), 1999, pp. 717-718
Citations number
14
Categorie Soggetti
Chemistry
Journal title
CHEMICAL COMMUNICATIONS
ISSN journal
13597345 → ACNP
Issue
8
Year of publication
1999
Pages
717 - 718
Database
ISI
SICI code
1359-7345(19990421):8<717:BOIIEC>2.0.ZU;2-4
Abstract
The interconversion of isopentenyl diphosphate (IPP) and dimethylallyl diph osphate (DMAPP) catalyzed by E. coli and S. pombe IPP isomerase proceeds wi th removal of the pro-R proton at C2 of IPP and addition of a water-derived proton to the re face of the C2-C3 double bond in DMAPP; this is the same stereochemistry observed for S. cerevisiae and rat liver enzymes.