Esterase catalysed enantioselective ring closure

Citation
Cv. Barker et al., Esterase catalysed enantioselective ring closure, CHEM COMMUN, (8), 1999, pp. 721-722
Citations number
11
Categorie Soggetti
Chemistry
Journal title
CHEMICAL COMMUNICATIONS
ISSN journal
13597345 → ACNP
Issue
8
Year of publication
1999
Pages
721 - 722
Database
ISI
SICI code
1359-7345(19990421):8<721:ECERC>2.0.ZU;2-O
Abstract
Porcine liver esterase catalyses the reaction of gamma-amino esters in wate r to give a mixture of the corresponding gamma-lactam and the hydrolysis pr oduct, deacylation of the acyl enzyme intermediate by ring closure occurs w ith a high enantioselectivity giving an ee of 90% for the formation of (S)- 5-phenyl-2-pyrrolidone from racemic ethyl 4-phenyl-4-aminobutanoate.