J. Olsovska et al., Direct resolution of optically active isomers on chiral packings containing ergoline skeleton. 6. Enantioseparation of profens, CHIRALITY, 11(4), 1999, pp. 291-300
The enantioselective behaviour of some underivatized 2-arylpropionic acids
(profens) and flobufen by HPLC using a terguride-based chiral stationary ph
ase was tested. X-ray analysis of crystals of the chiral selector and its c
omplexes with naproxen allowed a deeper insight into the enantiodiscriminat
ive process. The column stability and reproducibility, and the potential of
the packing for semipreparative scale separations were also determined. A
method for determining flobufen enantiomers and metabolites in plasma sampl
es is described. Chirality 11.291-300, 1999. (C) 1999 Wiley-Liss, Inc.