Direct resolution of optically active isomers on chiral packings containing ergoline skeleton. 6. Enantioseparation of profens

Authors
Olsovska, J Flieger, M Bachechi, F Messina, A Sinibaldi, M
Citation
J. Olsovska et al., Direct resolution of optically active isomers on chiral packings containing ergoline skeleton. 6. Enantioseparation of profens, CHIRALITY, 11(4), 1999, pp. 291-300
Citations number
42
Categorie Soggetti
Chemistry & Analysis
Journal title
CHIRALITY
ISSN journal
08990042 → ACNP
Volume
11
Issue
4
Year of publication
1999
Pages
291 - 300
Database
ISI
SICI code
0899-0042(1999)11:4<291:DROOAI>2.0.ZU;2-5
Abstract
The enantioselective behaviour of some underivatized 2-arylpropionic acids (profens) and flobufen by HPLC using a terguride-based chiral stationary ph ase was tested. X-ray analysis of crystals of the chiral selector and its c omplexes with naproxen allowed a deeper insight into the enantiodiscriminat ive process. The column stability and reproducibility, and the potential of the packing for semipreparative scale separations were also determined. A method for determining flobufen enantiomers and metabolites in plasma sampl es is described. Chirality 11.291-300, 1999. (C) 1999 Wiley-Liss, Inc.