Surgical treatment of thyroid-related orbitopathy can be accomplished by tr
ansorbital or endoscopic techniques. Transorbital surgery has advantages in
the orbital floor and lateral wall, and endoscopic decompression is best s
uited to the medial orbital wall. We describe a retrospective review of 16
orbits (10 patients) treated with surgery, combining endoscopic decompressi
on of the medial wall and a transorbital approach to the floor and lateral
wall. Follow-up averaged 20.8 months. Vision and field defects improved dra
matically in compressive optic neuropathy cases. Hertel measurements improv
ed, on average, 4.9 mm. Two patients with severe preoperative diplopia requ
ired strabismus surgery after decompression. Combined-approach decompressio
n is a safe and efficacious operation with conceptual advantages over curre
nt surgical techniques.