ACE-INHIBITORS CAPTOPRIL AND ENALAPRIL INDUCE REGRESSION OF LEFT-VENTRICULAR HYPERTROPHY IN HYPERTENSIVE PATIENTS WITH CHRONIC-RENAL-FAILURE

Background. Left ventricular hypertrophy is frequently noted in patien ts with moderate to severe chronic renal failure not requiring dialysi s. Recently, several studies have shown reversal of myocardial hypertr ophy in endstage renal disease with long-term pharmacological control of blood pressure, but it is unclear whether left ventricular mass reg resses or normalizes with antihypertensive treatment of patients with earlier stages of chronic renal failure. Methods. Seventy-two undialys ed patients with chronic renal failure, chronic mild-to-moderate hyper tension, and left ventricular hypertrophy were randomly assigned in a prospective study to either the captopril (n = 36) or enalapril group (n = 36). Blood pressure measurements, echocardiographic and Doppler p arameters were evaluated before treatment and at 6 and 12 months of th erapy. Results. During follow-up, six patients developed side-effects including dry cough, taste disturbances, skin rash and gastric intoler ance. In the captopril group there was a decrease in mean left ventric ular mass index by 12% after 6 months of treatment, which decreased by 20% after 12 months treatment. For enalapril, the average reduction o f myocardial mass after 6 months treatment was 14% and after 12 months treatment, the decrease was 19%. In both treatment groups there was s ignificant improvement of left ventricular filling dynamics. No deteri oration of left ventricular systolic function was observed. Conclusion s. Our results confirm that antihypertensive monotherapy with the ACE inhibitors, captopril and enalapril, in patients with chronic renal fa ilure results in regression of left ventricular mass index associated with a significant improvement in the diastolic function of the left v entricle without a demonstrable deterioration in left ventricular syst olic performance.