Sterol regulatory element-binding proteins: activators of cholesterol and fatty acid biosynthesis

Authors
Horton, JD Shimomura, I
Citation
Jd. Horton et I. Shimomura, Sterol regulatory element-binding proteins: activators of cholesterol and fatty acid biosynthesis, CURR OP LIP, 10(2), 1999, pp. 143-150
Citations number
36
Categorie Soggetti
Cardiovascular & Hematology Research
Journal title
CURRENT OPINION IN LIPIDOLOGY
ISSN journal
09579672 → ACNP
Volume
10
Issue
2
Year of publication
1999
Pages
143 - 150
Database
ISI
SICI code
0957-9672(199904)10:2<143:SREPAO>2.0.ZU;2-N
Abstract
A family of transcription factors designated sterol regulatory element-bind ing proteins (SREBPs) mediates the previously described end-product feedbac k regulation of cholesterol biosynthesis. In addition, SREBPs are emerging as important regulators of fatty acid synthesis. The current review focuses on the in-vivo regulation of SREBPs in liver and the coordinate regulation of SREBP-activated target genes. Curr Opin Lipidol 10:143-150, (C) 1999 Li ppincott Williams & Wilkins.