Effects of a standardized guggulsterone phosphate supplement on body composition in overweight adults: A pilot study

The purpose of this study was to determine the effects,of a guggulsterone p hosphate salt compound on body composition and mood states in overweight ad ults. In a double-masked, randomized, placebo-controlled study, 20 subjects with a body-mass index 25 kg/m(2) were separated into 1 of 3 groups. The e xperimental group received guggulsterones 750 mg and phosphate 1650 mg dail y, the placebo group received maltodextrin capsules, and the control,group received no treatment for 6 weeks. Subjects were instructed to follow the A merican Heart Association Step One diet and a 3-day-per-week circuit exerci se program. Body weight decreased significantly in the experimental group ( 3.2%, P < 0.05) and fat mass decreased significantly in the experimental (2 0.6%) and control (8.6%) groups (P < 0.01). However, between-group differen ces in weight loss mere not statistically significant. Profile of Mood Stat es (POMS)-fatigue decreased significantly in the experimental group (63.7%, P < 0.01), whereas POMS-vigor increased significantly in the experimental group (32.3%, P < 0.01) and decreased significantly in the placebo group (1 5.6%, P < 0.01). Results of this study suggest that,ingestion of a guggulst erone phosphate salt compound concurrent with regular exercise will result in a significant loss of body weight and improved mood states.