Quantitative systolic and diastolic transmyocardial velocity gradients assessed by M-mode colour Doppler tissue imaging as reliable indicators of regional left ventricular function after acute myocardial infarction

Aims The aim of this study was to determine whether myocardial velocity gra dients assessed by M-mode colour Doppler tissue imaging could be of clinica l relevance and represent reliable indicators of regional left ventricular function after acute myocardial infarction. Methods and Results Among 64 consecutive patients with a first acute myocar dial infarction, in 50 who had a marked asynergy in the parasternal short-a xis view at the mid-papillary muscle level, myocardial velocities and veloc ity gradients were assessed in the anteroseptum and posterior wall by M-mod e Doppler tissue imaging. Similar measurements were obtained in 11 matched healthy volunteers who served as a control group. In patients with anterior myocardial infarction, the peak myocardial veloci ty gradient in the anteroseptum was significantly lower when compared with controls (mean +/- [SD] 0.0 +/- 0.5 vs 1.1 +/- 0.7 s(-1) during systole, P < 0.01; and 0.3 +/- 0.6 vs 2.0 +/- 0.5 s(-1) during diastole, P < 0.01). Co nversely, the peak systolic myocardial velocity gradient in the posterior w all was significantly higher than in controls (2.6 +/- 1.2 vs 1.8 +/- 1.2 s (-1), P < 0.05). In patients with inferior myocardial infarction, the peak velocity gradient in the posterior wall was significantly lower when compar ed with healthy subjects (0.9 +/- 0.6 vs 1.8 +/- 1.2 s(-1) during systole a nd 1.4 +/- 1.4 vs 4.9 +/- 1.2 s(-1) during diastole, both P < 0.01). The pe ak systolic tissue velocity gradient in the anteroseptum was significantly higher than in controls (2.1 +/- 1.0 vs 1.1 +/- 0.7 s(-1), P < 0.01). Conclusion The present study indicates that myocardial velocity gradients a ssessed by M-mode Doppler tissue imaging are of clinical relevance for the characterization of ischaemic myocardial dysfunction after infarction and m ay provide quantitative assessment of segmental left ventricular function i n this clinical setting.