Aims Colour Doppler is the most widely used technique for assessing valve d
isease, but eccentric regurgitant jets cannot be visualized and measured by
conventional 2D techniques. We have developed a new procedure for three-di
mensional (3D) reconstruction of colour Doppler signals.
Methods and Results Fifty patients with mitral regurgitation underwent tran
soesophageal echocardiography and 3D acquisition. The severity of mitral re
gurgitation was assessed by angiography and the regurgitant volumes were me
asured by pulsed Doppler. The jet areas were calculated by planimetry from
conventional colour Doppler, the jet volumes were obtained by 3D Doppler. A
higher degree of mitral regurgitation was found in the patients with eccen
tric jets. While jet areas showed poor correlation with regurgitant volumes
(r = 0.61), jet volumes correlated significantly with regurgitant volumes
(r = 0.93; P < 0.001). While jet areas failed to identify patients with dif
ferent grades of regurgitation, jet volumes could so discriminate.
Conclusions 3D Doppler revealed new patterns of regurgitant flow and allowe
d a more accurate semiquantitative assessment of complex asymmetrical regur
gitant jets. Three-dimensional colour Doppler has a great potential for bec
oming a reference method for the assessment of patients with heart valve di
sease.