Synthesis and antimicrobial activities of monoindolyl- and bisindolyloximes

Six monoindolyl- and bisindolyloximes structurally related to protein kinas e C inhibitors bisindolylmaleimides were synthezised. They did not have pro tein kinase C inhibitory properties but exhibited interesting antimicrobial activities. Their antibacterial activities against several strains of path ogenic and non-pathogenic Gram-positive and Gram-negative bacteria are desc ribed. The bisindolyl monooxime isomers exhibited a marked activity against the three strains of Staphylococcus aureus tested and against Escherichia cold 1507E. (C) Elsevier, Paris.