New 9- or 10-arylpiperazinoalkyl substituted pyrimido- or diazepino[2,1-f]purines with partial or full 5-HT1A agonistic activity

Authors
Pawlowski, M Katlabi, J Drabczynska, A Duszynska, B Charakchieva-Minol, S Deren-Wesolek, A Tatarczynska, E Chojnacka-Wojcik, E Mokrosz, MJ Bojarski, AJ
Citation
M. Pawlowski et al., New 9- or 10-arylpiperazinoalkyl substituted pyrimido- or diazepino[2,1-f]purines with partial or full 5-HT1A agonistic activity, EUR J MED C, 34(2), 1999, pp. 167-175
Citations number
21
Categorie Soggetti
Chemistry & Analysis
Journal title
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
ISSN journal
02235234 → ACNP
Volume
34
Issue
2
Year of publication
1999
Pages
167 - 175
Database
ISI
SICI code
0223-5234(199902)34:2<167:N9O1SP>2.0.ZU;2-N
Abstract
5HT(1A) and 5HT(2A) receptor affinities of several gamma-(3'-chloro- or 2'- methoxyphenyl)-piperazinopropyl derivatives of pyrimido[2,1-f]purines or 1, 3-diazepino[2,1-f]purines are reported. Some behavioral models demonstrated that 1,3-dimethyl-9-{3-[4-(2'-methoxyphenyl)-1-piperazinyl]propyl}-2,4-dio xo-1,3,6,7,8,9-hexahydropyrimido[2,1-f]purine 5b and 1,3-dimethyl-9-{3-[4-( 2'-methoxyphenyl)-1-piperazinyl]propyl}-2,4,8-trioxo-1,3-dihydro-9H-pyrimid o[2,1-f]purine 8b, may be classified as partial agonist and a full agonist, respectively of pre- and post-synaptic 5HT(1A) receptors. (C) Elsevier, Pa ris.