Evaluation of ready-to-use liquid reagents for clinical chemistry in laboratory animals

We evaluated the ready-to-use liquid reagents for clinical chemistry (6 tes ts), to assess their suitability for use in the toxicology laboratory setti ng. Hitachi 736 automated analyzer was used for the analyses. The evaluatio n included the following studies: Precision, Linearity, Effects of interfer ence substances such as hemolytic hemoglobin, bilirubin, turbidity to the a nalytical values and correlation to the solid reagents, which are prepared each time they are needed. The precision and linearity data were within the reagents' specifications. Results of comparison of the liquid reagents and the solid reagents in analyzing plasma samples of rats, dogs and monkeys w ere generally good except for a bias in results for GOT and GPT, regardless of the animal species tested It is concluded that these types of liquid re agents can be used in clinical pathology examinations in animal studies.