Objective: To examine fecundability trends among sperm donors.
Design: Retrospective analysis.
Setting: University-based sperm bank and donor insemination program.
Patient(s): Sperm donors and recipients.
Intervention(s): A group of recipients underwent IUI with cryopreserved don
or sperm. Fecundability was calculated for 20 sperm donors over 800 insemin
ation cycles.
Main Outcome Measure(s): Average fecundability per donor was compared for t
he first 40 cycles of a donor's use and for those donors within a group of
more fertile recipients. Sperm parameters, recipient ages, and number of un
ique recipients for each donor were analyzed.
Result(s): Average donor fecundability is constant; however, individual don
ors demonstrated differences among their fecundabilities (overall mean, 0.0
9; range, 0.01-0.26). These differences persisted for donors among a group
of more fertile recipients (overall mean, 0.12; range, 0.02-0.35). A donor'
s fecundability at 15 cycles is predictive of his future performance.
Conclusion(s): Differences in fecundability exist among sperm donors which
cannot be discerned through routine semen parameters. Sperm donor fecundabi
lity should be analyzed periodically, and directors of sperm banks should c
onsider discontinuing use of a donor whose outcome is substandard. (C) 1999
by American Society for Reproductive Medicine.