CDNA characterization and chromosomal mapping of human Golgi SNARE GS27 and GS28 to chromosome 17

Transport of proteins along the exocytotic pathway is primarily achieved by vesicular intermediates. Two proteins, Gels SNAREs of 27 kDa, GS27, and of 28 kDa, GS28 (HGMW-approved nomenclature GOSR2 and GOSR1, respectively), a re important trafficking membrane proteins between the endoplasmic reticulu m and the Golgi and between Gels subcompartments. Here, we present the huma n GS27 and GS28 cDNA sequences. They encode predicted proteins of 212 and 2 50 amino acids, respectively. Chromosomal mapping analyses reveal that huma n GS27 is located on chromosome 17q21 and GS28 on approximately 17q11, The chromosomal location of GS27 near a locus implicated in familial essential hypertension and its known function in trafficking indicate that it is a po tential candidate gene for this disease. (C) 1999 Academic Press.