K. Kurokawa et al., Age-related change in peripheral nerve conduction: Compound muscle action potential duration and dispersion, GERONTOLOGY, 45(3), 1999, pp. 168-173
Background: We investigated the effect of age on nerve conduction parameter
s with special reference to the compound muscle action potential (CMAP) dur
ation and duration ratio. Method: We examined 295 subjects (aged 15-85 year
s old) with no previous history or present signs of peripheral neuropathy.
The subjects were divided into 3 groups: young (15-34 years old); intermedi
ate (35-64 years old), and old (65-85 years old), Results: CMAP amplitude w
as lower in the old group than in the young group; however, the CMAP ratio
(proximal CMAP/distal CMAP) did not change with age. The CMAP duration and
duration ratio did not differ among the 3 groups, The CMAP area was smaller
in the old group, but the area ratio was almost constant among the 3 group
s. Conclusion: We suggest that age-related changes in CMAP amplitude, durat
ion or area may occur uniformly, at least in the forearm and the calf segme
nt, in routine nerve conduction studies, The present findings also provide
useful a nd reliable information, regardless of age, in diagnosing peripher
al neuropathy.