Lateral microscopic extension of squamous cell carcinoma of the vulva

Purpose. The aim of this study was to measure the radial occult microscopic spread of tumor in patients with invasive squamous cell carcinoma of the v ulva. Materials and Methods. In the operating room the gross tumor border was mar ked. The pathologist took a radial section in each quadrant and measured th e distance of occult lateral spread of the tumor. Results. From 7/01/93 to 6/30/96, 24 tumors from 21 patients were studied. The mean maximum tumor diameter was 3.2 cm (0.5-7.0) and the mean depth of invasion was 9.1 mm (1.1-28.0). The gross and microscopic extent correlated in 20 tumors. Maximum lateral microscopic extent of the other 4 tumors was 3.5, 5 (to the margin), 10, and 16 mm. These 4 tumors were ulcerative and infiltrative and arose from or involved mucosa. Conclusion. The gross and microscopic periphery of most invasive squamous v ulvar cancers are approximately the same. Ulcerative tumors with an infiltr ative pattern of invasion which involve mucosal epithelium may be more like ly to extend beyond what is grossly apparent. Measurement of the tumor-free margin should be included in future studies, (C) 1999 Academic Press.