Frequency of invasive cancer in surgically excised vulvar lesions with intraepithelial neoplasia (VIN 3)

Objective, The aim of this study was to determine the frequency of invasive cancer found from specimens removed by surgical excision on patients with diagnosis of VIN 3, Methods. Seventy-eight patients with biopsy-proven vulvar intraepithelial n eoplasia 3 (VIN 3) were treated by surgical excision. Results. Sixteen patients (20.5%) were found to have invasion in the excise d surgical specimen. Superficial invasion was seen in 7 patients (9%), 9 we re noted to have >1 mm invasion (11.5%), and 1 patient had in situ Paget's disease (1.3%), Conclusion. Surgical excision should be considered a preferable method in m anagement of patients with VIN 3. (C) 1999 Academic Press.