Complete clinical responses to neoadjuvant chemotherapy for uterine serouscarcinoma

Three cases of serous carcinoma of the uterus with radiographically documen ted widespread metastases are presented, Following confirmation of histopat hology, all were treated with a standard regimen of carboplatin and paclita xel for eight courses with complete resolution of distant metastases on CT scan prior to postchemotherapy surgical exploration. Two patients had gross disease at laparotomy, and one had only microscopic tumor found in the ute rine specimen. This experience offers rationale for treatment of patients w ith widely metastatic uterine serous carcinoma or other relative contraindi cations to surgery with primary carboplatin and paclitaxel. In addition, we believe this experience supports the hypothesis that this regimen may resu lt in prolonged disease-free survival when employed as postsurgical adjuvan t therapy. (C) 1999 Academic Press.